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The opening theme is "Teardrop" by Massive Attack, although due to rights and licensing issues this music is not used for the show in the United Kingdom, Australia, Portugal, Spain, Italy, Israel, New Zealand and Latin America. In those countries, a piece of music named "House," composed by Scott Donaldson and Richard Nolan, is used. It was written specifically for the show. With the second series, this was replaced with a similar but different track. "Teardrop" itself does have lyrics, however for the opening credits only the beginning and ending sections of the song are used, which contain no lyrics.

House's birthday is June 11, 1959 - the same as Hugh Laurie's. This was shown in the second season ending episode. A close-up of his patient ID bracelet lists DOB 06-11-59 which, in U.S. date format, is June 11, 1959. 

Jesse Spencer, who plays Dr. Robert Chase, has several family ties to the medical profession: his father and two brothers are doctors in Australia while his sister is currently in medical school. When watching House, Spencer's brothers try to diagnose the problem based on the symptoms and medical jargon presented in the show. They also look for medical slip-ups in the dialogue.

The UK's Five showed the first season episode "Damned If You Do" out of sequence (in December), because it is near Christmas in the episode. 

In the episode "Clueless", House and Wilson are seen looking at House's list of recorded television shows, which included Blackadder, The New Yankee Workshop, SpongeBob Squarepants, The O.C., as well as a Monster Truck Jam. Hugh Laurie starred in Blackadder, and, in previous episodes, it has been revealed that House enjoys both The O.C. and monster trucks. House described his interest in The New Yankee Workshop by saying "It's a complete moron working with power tools. How much more suspenseful can you get?" The "moron" that House refers to is the show's host, Norm Abram, who is incidentally well known for his work on the PBS television show This Old House. The episode "Forever" mentions that House also likes to watch recorded episodes of The L Word, but "only on mute." 

House rides a Honda CBR1000RR Repsol replica motorcycle. 

Many of the wings in the hospital (e.g., Cuyler Wing and Witherspoon Wing) take their names from the dormitories at Princeton University. Some of the pictures in House's office also appear to be pictures of the campus. 

David Shore has said that the character of House is inspired by the fictional character Sherlock Holmes, particularly with regard to drug use and his desire (and capacity) to solve the insolvable. House uses Holmesian deductive techniques to diagnose his patients' problems. References to the sleuth range from the obvious (House's apartment number being 221B) to the subtle (his friendship with Dr. James Wilson and the similarities between the names "House" and "Holmes", and "Wilson" and "Watson").

In the episode where Wilson moves in with House (Season 2), House's tivo list is shown. One of the saved programs is Blackadder, featuring Hugh Laurie.

During Hugh Laurie's audition, David Shore says that Bryan Singer, one of the executive producers, said, "See, this is what I want: an American guy." Singer was completely unaware of the fact that Laurie is English.

Hugh Laurie auditioned for the part of Dr. House via video shot in a hotel bathroom in Namibia, where he was shooting the upcoming film Flight of the Phoenix (2004). "It was the only place with enough light," the actor claimed.

Sources: Wikipedia and IMDb